DMT ‘s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
DMT (N,N-Dimethyltryptamine) is a hallucinogenic tryptamine drug that occurs naturally in many plants and animals. It is also referred to as the “spirit molecule” due to the intense psychedelic experience.
Although lesser known than other psychedelics such as LSD or magic mushrooms, DMT produces a brief but intense visual and auditory hallucinogenic experience.
DMT is a Schedule I controlled substance in the United States; this means that it is illegal to manufacture, buy, possess, or distribute the drug. The substance has a high potential for abuse, no recognized medical use, and a lack of accepted safety parameters for the use of the drug.
DMT has no approved medical use in the United States. but can be used by researchers under a Schedule I research registration that requires approval from both the Drug Enforcement Administration (DEA) and the Food and Drug Administration (FDA).
Despite its illegal status, It is used in some religious ceremonies and various settings for an “awakening” or to obtain deep spiritual insight.